The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck or jaw. The CDK4/6 kinase is involved, with coregulatory partner cyclin D, in the G1-S transition. It is important to consider that it presents low to absent activity against other kinases. Available fields are: Gene name ( HGNC name or synonyms), Protein class, Chromosome, External identifier ( Ensembl gene, transcript or protein identifier, UniProt accession number, NCBI Entrez gene identifier), Subcellular location based on immunofluorescent staining in three different cell lines, Organ-, Tissue-, Cancer- and Cell line expression, Antibody validation results in four different assays ( IH=immunohistochemistry, IF=immunoflourescence, WB=Western blot, PA=Protein array), evidence scores and a filtration on Genes with antibodies only and Genes with knowledge-based annotated protein expression ( IH, IF). A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle. Palbociclib is a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor that acts by binding to the ATP pocket with an IC50 in the range of 9-15 nmol/L. ![]() ![]() Specific fields can be searched by using the "Fields"-function. The free text query word needs to be at least three characters long. The free text search will scan for complete and partial matches to gene names, gene synonyms, gene descriptions, external ( UniProt, Ensembl, NCBI Entrez Gene) gene and protein identifiers, protein classes, Gene Ontology identifiers and descriptions, antibody identifiers and image annotations. ![]() molecules (such as Apaf-1, AIF and caspase 3) (Beere et al. Molecular field extrema as descriptors of biological activity: Definition and validation. The search function can be used for free text search (type anything in the search field), or for more complex queries using "Fields" (see examples). activity, meaning that they recognize unfolded or aggregated proteins and.
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